衡道病理特邀撰稿作者翻译了WHO部分图⽚的图注，并用手帐的⽅式进行中英对照，且通过不同颜色的划线将晦涩难懂的英文单词与中⽂翻译同时标注，希望对专业英文的学习有所帮助。上一期分享了卵巢性索间质肿瘤中的纯性索肿瘤，本期将带来性索间质肿瘤中的混合性索-间质肿瘤。由于本篇目的以英文学习为主，篇幅有限，故未对各个疾病进行详细阐述。全部图片均来自WHO，若有不恰当之处，还请评论区指正。

WHO图注英文学习手帐

一、Sertoli-Leydig cell tumour

Sertoli-Leydig细胞瘤

Definition

Sertoli-Leydig cell tumours (SLCTs) are tumours composed of varying proportions of Sertoli and Leydigcells.

定义

Sertoli-Leydig细胞瘤(SLCTs)是由不同比例的Sertoli细胞和Leydig细胞组成的肿瘤。

ICD-O coding

8631/1 Sertoli-Leydig cell tumour NOS

ICD-O编码

8631/1 Sertoli-Leydig细胞瘤NOS

Essential and desirable diagnostic criteria

Essential: a sex cord-stromal tumour consisting of an admixtured of Sertoli cell and Leydig cell components.

Desirable: positivity for sex cord markers.

必需和理想的诊断标准

必需:一种性索间质肿瘤，由Sertoli细胞和Leydig细胞混合组成。

理想:性索标记阳性。

Fig. 1.95 Sertoli-Leydigcell tumour (SLCT). 

图1.95 Sertoli-Leydig细胞瘤(SLCT)。

A Well-differentiated SLCT, with open sertoliform tubules and Leydigcell clusters between tubules.

A高分化SLCT，可见sertoli细胞形成的开放的小管和小管之间的Leydig细胞簇。

B Moderately differentiated SLCT, with irregular anastomosing cords and closed sertoliform tubules admixed with plump eosinophilic Leydig cells.

B中分化SLCT，有不规则的吻合条索和封闭的sertoli细胞形成的小管，间质混杂肥胖的具有嗜酸性胞浆的Leydig细胞。

C Poorly differentiated SLCT, withstoriform arrangement of primitive gonadal stromal cells and rare individual Leydig cells. Other areas of this tumour showed closed sertoliform tubules and Leydig cells.

C低分化SLCT，原始性腺基质细胞席纹状排列，散在个别Leydig细胞。肿瘤的其他区域表现为封闭的sertoli细胞形成的小管结构和Leydig细胞。

D Heterologous intestnal mucinous differentiation in a moderately differentiated tumour.

D中分化肿瘤的异源性肠型黏液分化。

E Retiform differentiation in a moderately differentiated tumour. Panels B-E show tumours harbouring hotspot mutations in the RNase IIIb domain of DICER1.

E中分化肿瘤的网状分化。图B-E显示肿瘤在DICER1的RNase IIIb结构域中携带热点突变。

F FOXL2 immunohistochemistry showing staining of the sertoliform component and no staining of the Leydig cells, in a well-differentiated SLCT.

F 在高分化SLCT 中，免疫组化标记FOXL2 在sertoli成分中阳性，而Leydig细胞阴性。

Fig. 1.96 Sertoli-Leydig cell tumour. Cellular areas alternate with hypocellular areas in this intermediate-grade Sertoli-Leydig cell tumour, imparting a multinodular appearance on low-power examination.

图1.96 Sertoli-Leydig细胞瘤。中分化Sertoli- Leydig细胞瘤中，细胞丰富区与细胞稀疏区交替出现，低倍镜下呈多结节状。

二、Sex cord-stromal tumour NOS

性索间质肿瘤NOS

Definition

Sex cord-stromal tumour NOS is a tumour that lacks definitive characteristics of a specific tumour type.

定义

性索间质肿瘤NOS是一种缺乏特定类型肿瘤特征的肿瘤。

ICD-O coding

8590/1 Sex cord tumour NOS

ICD-O编码

8590/1性索肿瘤NOS

Essential and desirable diagnostic criteria

Essential: immunohistochemical findings that support a diagnosis of sex cord-stromal tumour, but histopathological feature of a specific tumour type are not present.

必需和理想的诊断标准

必需:免疫组织化学结果支持性索间质瘤的诊断，但没有特定肿瘤类型的组织病理学特征。

Fig.1.97 Sex cord-stromal tumour NOS. Both sex cord and stromal elements are present; the former can be highlighted by reticulin staining. The sex cord component lacks the cytological features of adult granulosa cell tumour and the tubular or cordlike architecture of Sertoli-Leydig cell tumour. This tumour is negative for mutationsin FOXL2 and DICER1.

图1.97性索间质肿瘤NOS，性索和间质成分均存在;前者可通过网状纤维染色显示。性索成分缺乏成人颗粒细胞瘤的细胞学特征，也缺乏Sertoli-Leydig细胞瘤的管状或条索状结构。该肿瘤无FOXL2 和 DICER1突变。

三、Gynandroblastoma

卵巢两性母细胞瘤

Definition

Gynandroblastoma is a sex cord-stromal tumour with elements of both female and male differentiation.

定义

卵巢两性母细胞瘤是一种性索间质肿瘤，具有女性和男性分化的特征。

ICD-O coding

8632/1 Gynandroblastoma

ICD-O编码

8632/1 卵巢两性母细胞瘤

Essential and desirable diagnostic criteria

Essential: a sex cord-stromal tumour showing an admixture o female and male elements.

必需和理想的诊断标准

必需:性索间质肿瘤，表现为男性和女性成分的混合。

Fig.1.98 Gynandroblastoma composed of Sertoli-Leydig cell tumour (left) and adultgranulosa cell tumour (right).

图1.98两性母细胞瘤由Sertoli-Leydig细胞瘤(左)和成年型卵巢颗粒细胞瘤组成(右）。

Fig.1.99 Gynandroblastoma composed of juvenile granulosa cell tumour (A) and moderately differentiatedSertoli-Leydig cell tumour with heterologous intestinal mucinous differentiation (B)

图1.99两性母细胞瘤由幼年型颗粒细胞瘤(A)和具有异源性肠型黏液分化的中分化Sertoli-Leydig细胞瘤(B)组成。